Pain is one of the most primal and yet complex signals our body sends. It warns us, protects us, and calls us to care for ourselves. Yet in our modern world, where stress, sedentary lifestyles, and chronic inflammation are on the rise, pain has often lost its pure protective function – it becomes a constant companion.
📑 Inhaltsverzeichnis
- Pain as a Signal of the Body
- Acute and Chronic Pain – Two Different Worlds
- The Plant World as a Source of Pain Therapy
- Why Conventional Pain Relievers Often Only Mask Symptoms
- The Endocannabinoid System – Regulator of Pain Perception
- Holistic Pain Therapy – More Than Just Symptom Management
- Natural Companions for Pain: PEA, MSM, and Willow Bark
- Awareness, Trust, and Personal Responsibility
- 💬 Fragen? Frag den Hanf-Buddy!
Increasingly, people are seeking natural ways to alleviate pain without burdening the body with chemical medications. In doing so, attention shifts to the interplay of body, mind, and psyche. Plant-based active compounds like CBD, but also PEA, MSM, or willow bark can help restore balance in the body and treat pain in a gentle, causal manner.
In this episode of the Holistic CBD Podcast, Leonie and Thomas Marisch discuss a topic that affects everyone: pain. Together, they explore why pain is so important for our body, how acute and chronic forms differ, and what natural remedies are available to relieve suffering sustainably.
This goes beyond just CBD and the endocannabinoid system, but also covers other natural substances like PEA, MSM, or the age-old willow bark. The episode aims to guide listeners toward a deeper understanding of pain and healing – and to show how body and mind can regain balance through conscious, natural approaches.
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Pain as a Signal of the Body
Pain is far more than an unpleasant sensation – it is a vital warning signal for survival. Leonie Marisch describes it as an evolutionary protection system designed to keep our body from harm. When we are injured, we feel pain so we stop in time and avoid further stress. Without this signal, humans in earlier times would have been defenseless against dangers. Pain teaches us to be mindful of our bodies and protect them from repeating harmful actions.
A simple example is a child who touches a hot stovetop once. The pain ensures that this experience remains permanently in memory. Pain is therefore also a learning signal – a built-in mechanism that protects us from repetition.
Acute and Chronic Pain – Two Different Worlds
Acute pain occurs when there is an immediate cause such as an injury or inflammation. Once the healing process is complete, the sensation of pain disappears. Chronic pain, on the other hand, persists even though the original cause has long since been resolved. The body has learned to feel pain even when there is no current trigger present.
The nervous system plays a central role in this. Repeated pain impulses strengthen neural connections in the brain – the body remembers pain. In diseases like fibromyalgia, this mechanism is particularly evident: even the smallest stimuli trigger strong pain responses. The organism finds itself in a kind of permanent memory of pain that has taken on a life of its own.
The Plant World as a Source of Pain Therapy
For centuries, humans have used plants to relieve pain. Willow bark led to the discovery of acetylsalicylic acid – better known as aspirin. Opium poppy became the basis for morphine, a powerful analgesic. And from the hemp plant came knowledge of the endocannabinoid system, which is central to modern pain research.
Thomas Marisch recalls a personal experience in the podcast episode: his father suffered from severe pain and received morphine, which left him apathetic. Only through the administration of CBD in highly concentrated form could the pain be relieved – without the side effects of conventional medications. This experience ultimately led to the development of his own CBD paste, which continues to help many people regulate their symptoms naturally.
Why Conventional Pain Relievers Often Only Mask Symptoms
Leonie and Thomas make clear that conventional pain relievers have their place, particularly in acute conditions. However, they usually only numb the receptors rather than address the cause. The body’s signal is suppressed, communication between cells is disrupted. This shifts the problem rather than solving it.
With prolonged use, dependence can develop – particularly with opioid-based medications. Nature offers a different path: instead of blocking processes in the body, it supports the body’s own communication and promotes self-regulation. CBD is an example of this. It engages with the endocannabinoid system, which is significantly involved in the perception and regulation of pain.
The Endocannabinoid System – Regulator of Pain Perception
The endocannabinoid system (ECS) is the body’s own network that influences virtually all biological processes. Its receptors are found in the brain, central nervous system, and skin. It controls how intensely we perceive pain and how our body responds to it. When this system becomes imbalanced, pain can be felt excessively.
CBD helps restore this balance. It prevents the too-rapid breakdown of the body’s own cannabinoids like anandamide – also known as the „molecule of bliss.“ This regulates the pain threshold and allows the nervous system to process stimuli more effectively. At the same time, CBD has anti-inflammatory effects and supports the body in addressing pain at its root, rather than suppressing it.
Leonie explains clearly that CBD does not „switch off“ pain, but rather enables the body to properly classify it. In shock – for example after an accident – the body itself produces more anandamide to remain functional. Similarly, CBD supports this natural balance by activating the endocannabinoid system and improving the management of pain.
Holistic Pain Therapy – More Than Just Symptom Management
A central point of the podcast episode is the holistic approach to pain therapy. For Leonie, this means treating not only physical symptoms but also including mental and emotional factors. Pain is always also a message from the body – an expression of inner imbalance.
Humans have, in her view, the capacity for self-healing. Medications and plant-based substances can help, but true healing occurs through awareness, rest, and mindfulness. The holistic approach therefore encompasses body, mind, and spirit.
CBD can be an important catalyst here – as can other natural active compounds that work in a complementary way. What is crucial is to take responsibility for one’s own health again and take pain seriously as a signal, rather than numbing it.
Natural Companions for Pain: PEA, MSM, and Willow Bark
In addition to CBD, Leonie introduces other natural substances that can support pain management. PEA (Palmitoylethanolamide) is an endogenous fatty acid amide that has anti-inflammatory and pain-relieving properties. It protects cells and tissues from oxidative stress and is successfully used in both human and veterinary medicine – for arthritis, migraines, irritable bowel syndrome, menstrual discomfort, or neuropathic pain.
MSM (Methylsulfonylmethane) is an organic sulfur compound involved in numerous metabolic processes. It supports detoxification, promotes the formation of enzymes and amino acids, and can alleviate joint problems, muscle soreness, or inflammation. Since sulfur is often lacking in modern diets, targeted supplementation can be beneficial.
Willow bark, in turn, is the plant original behind the active ingredient in aspirin. It reduces fever, reduces inflammation, and relieves pain – especially with acute pain, flu, or mild joint complaints. As a tea or extract, it offers a mild yet effective alternative to synthetic preparations. Together, these natural remedies form a foundation for addressing pain at its source without burdening the body with chemical substances.
Awareness, Trust, and Personal Responsibility
At the end of the podcast episode, Leonie and Thomas emphasize that healing does not happen only at the physical level. Belief in one’s own regenerative capacity and willingness to take responsibility for your own body are decisive. Those who understand pain as a message and view it not as an enemy but as an indicator of a deeper cause can experience holistic healing.
The connection of knowledge, nature, and inner attitude forms the core of sustainable pain therapy – supported by CBD and other natural substances that accompany the body on its path to balance.
Further Articles on This Topic
- The Endocannabinoid System, Your Inner Regulator
- Why CBD Isn’t Working for You – and What You Can Do About It!
- VIP36 – a New Cannabinoid in Pain Medicine
- How CBD Helps You Manage Stress Better
- Differences in the Effects of CBD and CBG






































